Unfortunately, there are a number of reasons that make progressive disease difficult to clinically study in a rigorous manner: 1. For one, there are poor animal models of progressive disease, which makes doing basic laboratory research challenging. Dr. Mueller in our lab is working on such an animal model. 2. It’s also very difficult to measure the worsening in progressive disease because there are no biomarkers for progression and our outcome measures are not very good. The outcomes in...
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