An article was recently published in the journal, Neurology, which compared the cognitive function of 20 patients with MS who smoked cannabis to 19 MS patients who did not smoke. The patients were matched for a variety of variables such as age, education level, etc… The authors found that cannabis users performed worse on a variety of cognitive tasks and there were also some differences in brain activity, as measured by functional MRI. Although cannabis has shown to be of some benefit in spasticity, the side effects of cognitive dysfunction and fatigue likely outweigh any medical benefit for most patients with MS.