Dr. Duson Stefoski from Rush University in Chicago spoke at Grand Rounds this morning.  Dr. Stefoski is the Director of the Rush Multiple Sclerosis Center and has extensive experience in the diagnosis and management of Progressive Multifocal Leukoencephalopathy (PML). PML is the infection associated with prolonged Tysabri administration, for which there are no approved treatments.  Dr. Stefoski presented an experimental protocol for the treatment of PML, which has shown promising results in a small number of patients.  PML remains a rare but very serious condition and this novel research is a welcome approach for the IMSMP physicians to consider.